Evolution of human influenza a viruses in nature: Sequential mutations in the genomes of new H1N1 isolates
Identifieur interne : 002913 ( Main/Exploration ); précédent : 002912; suivant : 002914Evolution of human influenza a viruses in nature: Sequential mutations in the genomes of new H1N1 isolates
Auteurs : James F. Young [États-Unis] ; Ulrich Desselberger [États-Unis] ; Peter Palese [États-Unis]Source :
- Cell [ 0092-8674 ] ; 1979.
English descriptors
- Teeft :
- Academic press, Accurate comparisons, Additional spots, American society, Annual meeting, Antibody pressure, Antigenic, Antigenic drift, Antigenic variation, Biochemical evidence, Common ancestry, Desselberger, Different branches, Disease control, Divergent evolution, Evolutionary scheme, Evolutionary tree, Fingerprint, Gene derivation, Genes coding, Genetic relatedness, Genetic variants, Genetic variation, Genome, Hlnl, Hlnl strains, Hlnl viruses, Human influenza strains, Human influenza viruses, Influenza, Influenza virus, Influenza virus genome, Influenza virus rnas, Influenza virus strains, Influenza viruses, Kendal, Limited number, Monoclonal antibodies, Mutation, Mutational changes, Nakajima, Nonstructural protein, Oligonucleotide, Oligonucleotide changes, Oligonucleotide differences, Oligonucleotide fingerprinting, Oligonucleotide fingerprints, Oligonucleotide mapping, Oligonucleotide maps, Oligonucleotide patterns, Oligonucleotides, Palese, Pandemic, Particular gene, Particular strain, Peptide mapping, Polyacrylamide, Pyrimidine residues, Rapid sequencing technique, Recombinational event, Resistant oligonucleotides, Ribonuclease, Rna, Schild, Sequence analysis, Sequencing, Sequencing technique, Sequential mutations, Single base change, Surface glycoproteins, Surface proteins, Viral, Viral rnas, Virus, World health.
Abstract
Abstract: The genetic variation of the new pandemic H1N1 influenza A viruses isolated in 1977 was analyzed by two-dimensional oligonucleotide fingerprinting and RNA sequencing. Differences were observed in the fingerprints of the RNAs of these viruses, and analysis of the changes suggested that sequential mutations occurred in their genomes. Based on these data, a scheme is presented which proposes divergent evolution of strains from a common ancestry. Furthermore, it was found that mutations were not restricted to the genes coding for the hemagglutinin and the neuraminidase, but were scattered throughout the genome, suggesting that selective antibody pressure is not solely responsible for the emergence of genetic variants. Our data also strengthen the hypothesis that the new H1N1 influenza virus strains are derived from strains circulating in 1950.
Url:
DOI: 10.1016/0092-8674(79)90355-6
Affiliations:
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Differences were observed in the fingerprints of the RNAs of these viruses, and analysis of the changes suggested that sequential mutations occurred in their genomes. Based on these data, a scheme is presented which proposes divergent evolution of strains from a common ancestry. Furthermore, it was found that mutations were not restricted to the genes coding for the hemagglutinin and the neuraminidase, but were scattered throughout the genome, suggesting that selective antibody pressure is not solely responsible for the emergence of genetic variants. Our data also strengthen the hypothesis that the new H1N1 influenza virus strains are derived from strains circulating in 1950.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Young, James F" sort="Young, James F" uniqKey="Young J" first="James F." last="Young">James F. Young</name></region><name sortKey="Desselberger, Ulrich" sort="Desselberger, Ulrich" uniqKey="Desselberger U" first="Ulrich" last="Desselberger">Ulrich Desselberger</name><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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